Retatrutide works better than Semaglutide and Tirzepatide because it targets THREE hunger and metabolism related hormone pathways instead of just one or two. Semaglutide mainly reduces appetite, and tirzepatide reduces appetite AND improves how your body handles sugar. Retatrutide does BOTH of those things, PLUS it activates a third pathway that boosts your metabolism and helps your body burn fat more aggressively. (Especially deep belly fat and liver fat.) This combination means you eat less and your body burns more, which leads to much larger and faster weight loss.

     Another big reason it works so well is the balance of these three signals. The GIP and GLP-1 parts help control hunger and improve blood sugar, while also making the stronger fat-burning signal from glucagon easier to tolerate. Because of this balance, people can take higher doses without feeling too sick, which lets the drug work at full strength. Overall, retatrutide doesn’t just quiet your appetite, it also cranks up your body’s fat-burning system in a way the others can’t.